Malarial anemia and STAT6
نویسندگان
چکیده
منابع مشابه
Malarial anemia and STAT6.
M alaria infection places a huge economic burden on the developing world. It has been estimated that annually there are over 500 million episodes and it is responsible for 18% of childhood deaths in sub-Saharan Africa. 1 Infection in the human host is initiated by a bite from a female anopheline mosquito during which sporozoites enter the body and home to the liver initiating the hepatic phase ...
متن کاملSTAT6-mediated suppression of erythropoiesis in an experimental model of malarial anemia.
BACKGROUND The contribution of pro-inflammatory cytokines to the pathogenesis of malarial anemia has been studied extensively but the roles of Th2 cytokines remain unknown. Here, we investigated the role of signal transducer and activator of transcription (STAT)6-mediated responses in erythropoietic suppression during acute malaria infection in mice. DESIGN AND METHODS Naïve and/or erythropoi...
متن کاملMIF magnifies malarial anemia
Mast cells that accumulate cholesterol precursors in their membranes tend to overreact, according to Kovarova and colleagues on page 1161. This mast cell hyperresponsiveness might help explain why patients with a genetic disease known as Smith-Lemli-Opitz syndrome (SLOS) are prone to food allergies. Patients with SLOS have abnormally low levels of circulating cholesterol— and a corresponding ab...
متن کاملSevere Malarial Anemia: Innate Immunity and Pathogenesis
Greater than 80% of malaria-related mortality occurs in sub-Saharan Africa due to infections with Plasmodium falciparum. The majority of P. falciparum-related mortality occurs in immune-naïve infants and young children, accounting for 18% of all deaths before five years of age. Clinical manifestations of severe falciparum malaria vary according to transmission intensity and typically present as...
متن کاملMalarial anemia: of mice and men.
Severe malaria is manifest by a variety of clinical syndromes dependent on properties of both the host and the parasite. In young infants, severe malarial anemia (SMA) is the most common syndrome of severe disease and contributes substantially to the considerable mortality and morbidity from malaria. There is now growing evidence, from both human and mouse studies of malaria, to show that anemi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Haematologica
سال: 2009
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2008.002311